PW01-018 – Circulating endothelial biomarkers in FMF
نویسندگان
چکیده
Methods Forty FMF patients and eighteen healthy controls with no known cardiovascular risk factors were included. All patients were receiving regular colchicine treatment and examinations were performed during attack-free periods. Serum samples were used for the determination of high sensitive C-reactive protein (hs-CRP), tissue factor (TF), tissue plasminogen activator (t-PA) and osteoprotegerin (OPG). Plasma samples were used for the determination of asymmetric dimethylarginine (ADMA) and thrombomodulin (TM).
منابع مشابه
PW01-022 – Dissociation between CRP and SAA in FMF
Methods CRP and SAA were systematically measured during the follow-up of consecutive attack-free FMF outpatients seen in a pediatric and an adult French reference center. Dissociations between CRP and SAA were defined by normal CRP (<5mg/L) and elevated SAA (group A), or elevated CRP and normal SAA (<10mg/L) (group B). Demographic data, genotype, clinical characteristics of FMF, and treatment w...
متن کاملPW01-031 – Treatment of FMF in middle and old age
Introduction Current recommendations for the treatment of familial Mediterranean fever (FMF) are based largely on the observation of FMF patients receiving colchicine therapy in childhood and young age. The adequate colchicine therapy led to more and more patients survive to that age. In addition, there are national peculiarities of FMF. For example, in Armenia, even before the massive use of c...
متن کاملEndothelial biomarkers in patients with familial Mediterranean fever associated vascular disease and vasculopathy
Objectives FMF is an autosomal recessive disease, caused by mutations in the MEFV gene, encoding the pyrin protein associated with the interleukin-1b related inflammation cascade. In FMF overproduction of IL-1b and uncontrolled TNF-a release has been documented. These cytokines mediate activation of endothelial cells causing sustained inflammatory response and endothelial cell dysfunction[]. Va...
متن کاملPW01-024 – Phenotypic analysis of a MEFV negative FMF cohort
Introduction Familial Mediterranean fever (FMF) is an inherited autosomal recessive disorder, ethnically restricted and commonly found among individuals of Mediterranean descent, caused by MEditerranean FeVer gene (MEFV) mutations on the chromosome 16. It is the most frequent periodic febrile syndrome among autoinflammatory syndromes. Eighty % of patients with FMF have MEFV mutations, while aro...
متن کاملPW01-028 – Developing a new severity score for FMF
Introduction Severity is a basic feature that defines the prognosis of a disease. FMF presents with a variety of clinic and laboratory manifestations affecting severity, and evaluation of prognosis is an elusive task. Different severity scores have been previously proposed for FMF, and commonly used ones include Mor, Pras and Tel Hashomer severity scores however recent studies showed that there...
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2013